Product Name: Doxorubicin (Adriamycin) HClSubtitle: Antitumour antibiotic,inhibits TOPO II.Biological Activity: Biological Activity of Doxorubicin (Adriamycin) HClAntitumor antibiotic agent that inhibits DNA topoisomerase II. DNA intercalator that inhibits nucleic acid synthesis…
Product Name: Dexrazoxane HCl (ICRF-187, ADR-529)Subtitle: Topoisomerase II inhibitor,intracellular ion chelator,cardioprotective agentBiological Activity: SMLES: CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2.ClCAS NO: 396091-73-9Standard In CHIKey: PI4K inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C11H16N4O4.HClM.Wt: 304.73General Tips: For…
Product Name: ClofarabineSubtitle: Antimetabolite,inhibit DNA polymerase and ribonucleotide reductaseBiological Activity: Biological Activity of ClofarabineDeoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and…
Product Name: Gemcitabine HClSubtitle: Inhibits DNA synthesis,deoxycytidine analogBiological Activity: Biological Activity of Gemcitabine HClDeoxycytidine analog that inhibits DNA synthesis. Metabolized to form gemcitabine triphosphate (dFdCTP) and gemcitabine diphosphate (dFdCDP). dFdCTD…
Product Name: NelarabineSubtitle: Prodrug of ara-G for T-LBL/T-ALLBiological Activity: SMLES: COC1=NC(=NC2=C1N=CN2C3C(C(C(O3)CO)O)O)NCAS NO: 888216-25-9Standard In CHIKey: IXOXBSCIXZEQEQ-KBNQYOMWSA-NmTOR inhibitorsStandard InChI: InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10?/m1/s1Typrof Compound: Appearance: Formula: C11H15N5O5M.Wt: 297.27General Tips: For obtaining a higher solubility…
Product Name: GatifloxacinSubtitle: Fluoroquinolone antibiotic,inhibits bacterial TOPO IIBiological Activity: Biological Activity of GatifloxacinFluoroquinolone antibiotic. Inhibits bacterial type II topoisomerases (IC50 values are 0.109 and 13.8 μg/ml for E.coli DNA gyrase…
Product Name: DaptomycinSubtitle: Calcium-dependent antibioticBiological Activity: Biological Activity of DaptomycinLipopeptide, calcium-dependent antibiotic. Exhibits potent bacteriocidal activity against most gram-positive bacteria in vitro and in vivo, including antibiotic-resistant strains such as…
Product Name: UridineSubtitle: Biological Activity: Biological Activity of Uridine 1. Uridine has protective effects against drug-induced fatty liver, can prevent tamoxifen-induced fatty liver appeared to depend on the pyrimidine salvage…
Product Name: Topotecan hydrochlorideSubtitle: Topoisomerase 1 inhibitorBiological Activity: Biological Activity of Topotecan hydrochloride 1. Topotecan hydrochloride, a topoisomerase I inhibitor, capable of inhibiting tumoral growth in animal models of retinoblastoma.…
Product Name: GenisteinSubtitle: AR agonistBiological Activity: Biological Activity of Genistein Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds…