Product Name: CX-5461
Subtitle: Pol I-mediated rRNA synthesis inhibitor
Biological Activity: Biological Activity of CX-5461Description CX-5461 is an inhibitor of rRNA synthesis with IC50 of 142 nM for Pol I-driven transcription of rRNA, Targets Pol I HCT-116 A375 MIA PaCa-2 IC50 142 nM 167 nM (ED50) 58 nM (ED50) 74 nM (ED50
SMLES: CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C
CAS NO: 244218-51-7
Standard In CHIKey: GPCR19 inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C27H27N7O2S
M.Wt: 513.61
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/260/2/865
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Limited solubility
Storage:
Purity: >98%
Chemical Name: 2-(4-methyl-1,4-diazepan-1-yl)-N-[(5-methylpyrazin-2-yl)methyl]-5-oxo-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide