Product Name: ISRIB (trans-isomer)
Subtitle: PERK inhibitor,potent and selective
Biological Activity: Biological Activity of ISRIB (trans-isomer)Integrated stress response (ISR) inhibitor; reverses the effects of eIF2α phosphorylation (IC50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2	
SMLES: C1CC(CCC1NC(=O)COC2=CC=C(C=C2)Cl)NC(=O)COC3=CC=C(C=C3)Cl
CAS NO: 174484-41-4
Standard In CHIKey: Nucleoside Antimetabolite_Analog inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C22H24Cl2N2O4
M.Wt: 451.34
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/260/2/509
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 10 mM in DMSO with gentle warming
Storage: Store at +4℃
Purity: >98%
Chemical Name: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]