Product Name: L189
Subtitle: inhibitor of human DNA ligases I, III and IV
Biological Activity: Biological Activity of L189DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision
SMLES: S=C(NC1=O)NC(N)=C1/N=CC2=CC=CC=C2
CAS NO: 275371-94-3
Standard In CHIKey: HCN Channel inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C11H10N4OS
M.Wt: 246.29
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/260/3/1441
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO
Storage: Store at -20℃
Purity: >98%
Chemical Name: 6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone