Product Name: OF-1
Subtitle: BRPF1B and BRPF2 bromodomain inhibitor
Biological Activity: Biological Activity of OF-1Selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). Exhibits 39-fold selectivity for BRPF1B and BRPF2 over BRD4. Accelerates FRAP recovery at 5 μM in a BRPF2 FRAP assay.
SMLES: CN1C2=C(C=C(OC)C(NS(=O)(C3=C(C)C=C(Br)C=C3)=O)=C2)N(C)C1=O
CAS NO: 198474-05-4
Standard In CHIKey: CNS-penetrant_Compound_Library inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C17H18BrN3O4S
M.Wt: 440.31
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/261/3/879
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 20 mM in DMSO
Storage: Store at +4℃
Purity: >98%
Chemical Name: 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide