Product Name: PF-477736
Subtitle: Chk1 inhibitor
Biological Activity: Biological Activity of PF-477736Description PF-477736 is a selective, potent and ATP-competitive inhibitor of Chk1 with a Ki value of 0.49 nM. Targets Chk1 VEGFR2 Fms YES Chk2 IC50 0.49 nM(Ki) 8 nM(Ki) 10 nM(Ki) 14 nM(Ki) 47 nM(Ki)
SMLES: O=C(C(C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])([H])N([H])[H])N([H])C2=C([H])C3=C4C(N=C(C5=C([H])N(C([H])([H])[H])N=C5[H])C4=C([H])N([H])N([H])C3=O)=C2[H]
CAS NO: 364782-34-3
Standard In CHIKey: APC inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C22H25N7O2
M.Wt: 419.48
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/260/1/427
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (R)-2-amino-2-cyclohexyl-N-(2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-4H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide