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Pigott HE, Leventhal AM, Alter GS, Boren JJ Efficacy and effectiveness of antidepressants: present status of study. Psychotherapy and psychosomatics 79: 267279. doi:10.1159/000318293. 47. Fitzgerald PB, Laird AR, Maller J, Daskalakis ZJ A meta-analytic study of changes in brain activation in depression. Human brain mapping 29: 683695. doi:ten.1002/hbm.20426. 48. Tansey KE, Guipponi M, Perroud N, Bondolfi G, Domenici E, et al. Genetic predictors of response to serotonergic and noradrenergic antidepressants in important depressive disorder: a genome-wide Epigenetic Reader Domain Analysis of individual-level data and a meta-analysis. PLoS medicine 9: e1001326. doi:10.1371/journal.pmed.1001326. 49. Hek K, Demirkan A, Lahti J, Terracciano A A Genome-Wide Association Study of Depressive Symptoms. Biological psychiatry 73: 667 678. doi:ten.1016/j.biopsych.2012.09.033. 50. Dew MA, Reynolds CF, Houck PR, Hall M, Buysse DJ, et al. Temporal profiles of the course of depression during remedy. Predictors of pathways toward recovery within the elderly. Archives of general psychiatry 54: 10161024. 51. Pigeon WR, Hegel M, Unutzer J, Fan M-Y, Sateia MJ, et al. Is insomnia a perpetuating factor for late-life depression within the IMPACT cohort Sleep 31: 481488. 52. Lichstein K, Wilson N, Johnson C Psychological treatment of secondary insomnia. Psychology and aging 15: 232240. doi:10.1037//08827974.I5.2.232. 53. Rybarczyk B, Lopez M, Benson R, Alsten C, Stepanski E Efficacy of two behavioral remedy programs for comorbid geriatric insomnia. Psychology and Aging 17: 288298. doi:ten.1037//0882-7974.17.2.288. 54. Zimmerman M, McGlinchey JB, Young D, Chelminski I Dia.C Major Depression. Biological Psychiatry 54: 573583. doi:10.1016/S0006-322301866-8. 35. Rush AJ, Bernstein IH, Trivedi MH, Carmody TJ, Wisniewski S, et al. An Evaluation of the Quick Inventory of Depressive Symptomatology and the Hamilton Rating Scale for Depression: A Sequenced Therapy Alternatives to Relieve Depression Trial Report. Biological psychiatry 59: 15857111 493501. doi:ten.1016/j.biopsych.2005.08.022. 36. Marks IM Behavioural Psychotherapy. Bristol: John Wright. 37. Mundt JC, Marks IM, Shear MK, Greist JH The Perform and Social Adjustment Scale: a easy measure of impairment in functioning. The British Journal of Psychiatry 180: 461464. doi:10.1192/bjp.180.5.461. 38. Heiberger RM, Holland B Statistical Analysis and Data Display: An Intermediate Course with Examples in S-PLUS, R, and SAS. Springer. 39. Gromping U Relative Significance for Linear Regression in R: The Package relaimpo. Journal of Statistical Software 17: 127. 40. Johnson JW, Lebreton JM History and Use of Relative Importance Indices in Organizational Investigation. Organizational Investigation Strategies 7: 238 257. doi:ten.1177/1094428104266510. 41. Kruskal W, Majors R Ideas of Relative Significance in Current Scientific Literature. The American Statistician 43: 26. 42. Gromping U Estimators of Relative Significance in Linear Regression Primarily based on Variance Decomposition. The American Statistician 61: 139147. doi:10.1198/000313007X188252. 43. Muthen BO, Muthen L Mplus User’s Guide, seventh edition. Los Angeles: Muthen & Muthen. 44. R Development Core Team R: A language and environment for statistical computing. 45. Regier DA, Narrow WE, Clarke DE, Kraemer HC, Kuramoto SJ, et al. DSM-5 Field Trials within the United States and Canada, Part II: Test-Retest Reliability of Selected Categorical Diagnoses. The American journal of psychiatry 170: 5970. doi:10.1176/appi.ajp.2012.12070999. 46. Pigott HE, Leventhal AM, Alter GS, Boren JJ Efficacy and effectiveness of antidepressants: current status of research. Psychotherapy and psychosomatics 79: 267279. doi:10.1159/000318293. 47. Fitzgerald PB, Laird AR, Maller J, Daskalakis ZJ A meta-analytic study of changes in brain activation in depression. Human brain mapping 29: 683695. doi:10.1002/hbm.20426. 48. Tansey KE, Guipponi M, Perroud N, Bondolfi G, Domenici E, et al. Genetic predictors of response to serotonergic and noradrenergic antidepressants in big depressive disorder: a genome-wide analysis of individual-level information and a meta-analysis. PLoS medicine 9: e1001326. doi:ten.1371/journal.pmed.1001326. 49. Hek K, Demirkan A, Lahti J, Terracciano A A Genome-Wide Association Study of Depressive Symptoms. Biological psychiatry 73: 667 678. doi:ten.1016/j.biopsych.2012.09.033. 50. Dew MA, Reynolds CF, Houck PR, Hall M, Buysse DJ, et al. Temporal profiles of your course of depression during treatment. Predictors of pathways toward recovery in the elderly. Archives of general psychiatry 54: 10161024. 51. Pigeon WR, Hegel M, Unutzer J, Fan M-Y, Sateia MJ, et al. Is insomnia a perpetuating factor for late-life depression inside the IMPACT cohort Sleep 31: 481488. 52. Lichstein K, Wilson N, Johnson C Psychological remedy of secondary insomnia. Psychology and aging 15: 232240. doi:ten.1037//08827974.I5.2.232. 53. Rybarczyk B, Lopez M, Benson R, Alsten C, Stepanski E Efficacy of two behavioral therapy programs for comorbid geriatric insomnia. Psychology and Aging 17: 288298. doi:10.1037//0882-7974.17.2.288. 54. Zimmerman M, McGlinchey JB, Young D, Chelminski I Dia.