Product Name: AG-490
Subtitle: JAK2/EGFR inhibitor
Biological Activity: Biological Activity of AG-490Selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Inhibitor of JAK2, JAK3/STAT, JAK3/AP-1 and JAK3/MAPK pathways and potently inhibits cytokine-independent
SMLES:
CAS NO: 163768-50-1
Standard In CHIKey: Vitamin D Related inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C17H14N2O3
M.Wt: 294.3
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/254/3/774
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 20 mM in ethanol and to 100 mM in DMSO
Storage: Store at RT
Purity: >98%
Chemical Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide