Product Name: CC0651
Subtitle: E2 enzyme inhibitor
Biological Activity: Biological Activity of CC0651Allosteric inhibitor of human Cdc34. Inhibits hCdc34-mediated ubiquitination of p27Kip1 (IC50 = 1.72 μM). Exhibits selectivity for hCdc34 over Uba1, Ube2G1, UbcH7, UbcH5, Ube2N (Ubc13), Ube2R2, SMURF2, SspH1 and Rnf168.
SMLES: COC/C(O)=N/[C@@]([C@@](O)([H])[C@](O)([H])C(O)=O)([H])CC1=CC=C(C2=CC(Cl)=CC(Cl)=C2)C=C1
CAS NO: 1140909-48-3
Standard In CHIKey: FDA-approved_Drug_Library inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C20H21Cl2NO6
M.Wt: 442.29
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/26/3/243
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in 1eq. NaOH and to 100 mM in DMSO
Storage: Store at -20℃
Purity: >98%
Chemical Name: (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid