Product Name: CEP 1347
Subtitle: JNK inhibitor
Biological Activity: Biological Activity of CEP 1347Inhibitor of c-jun N-terminal kinase (JNK) signaling. Rescues motor neurons undergoing apoptosis (EC50 = 20 nM). Blocks Aβ-induced cortical neuron apoptosis (EC50 ~51 nM). Does not inhibit ERK1 activity. Neuroprotective
SMLES: O=C([C@@H](C1)[C@]2(C)O[C@@H]1N3C4=C5N2C(C=CC(CSCC)=C6)=C6C5=C(CNC7=O)C7=C4C8=C3C=CC(CSCC)=C8)OOC
CAS NO: 1639411-87-2
Standard In CHIKey: WMBUVOLZSWTKMP-KQFGJPIXSA-NAdiponectin Receptor inhibitors
Standard InChI: InChI=1S/C33H33N3O5S2/c1-5-42-15-17-7-9-23-19(11-17)27-28-21(14-34-31(28)37)26-20-12-18(16-43-6-2)8-10-24(20)36-30(26)29(27)35(23)25-13-22(32(38)41-39-4)33(36,3)40-25/h7-12,22,25H,5-6,13-16H2,1-4H3,(H,34,37)/t22-,25+,33+/m1/s1
Typrof Compound:
Appearance:
Formula: C33H33N3O5S2
M.Wt: 615.76
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/266/2/732
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 10 mM in DMSO
Storage: Store at -20℃
Purity: >98%
Chemical Name: (9S,10R,12R)-5-16-Bis[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester