Product Name: CO-1686 (AVL-301)
Subtitle: EGFR inhibitor
Biological Activity: Biological Activity of CO-1686 (AVL-301)Description CO-1686 is an irreversible and orally delivered inhibitor of EGFR with IC50 values of 21.5 nM and 303.3 nM for L858R/T790M mutant EGFR and wild-type EGFR, respectively. Targets L858R/T790M mutant
SMLES: CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC
CAS NO: 1453848-26-4
Standard In CHIKey: Wnt inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C27H28F3N7O3
M.Wt: 555.55
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/254/3/1107
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide