Product Name: Cabozantinib (XL184, BMS-907351)
Subtitle: VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor
Biological Activity: Biological Activity of Cabozantinib (XL184, BMS-907351)Potent VEGFR inhibitor (IC50 = 0.035 nM); also inhibits c-Met, KIT, RET, FLT4, AXL, FLT3, FLT1 and Tie2 (IC50 values are 1.3, 4.6, 5.2, 6, 7, 11.3, 12 and 14.3 nM, respectively). Induces intratumoral
SMLES: COc1cc2c(ccnc2cc1OC)Oc3ccc(cc3)NC(=O)C4(CC4)C(=O)Nc5ccc(cc5)F
CAS NO: 873225-46-8
Standard In CHIKey: Ribosomal S6 Kinase RSK) inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C28H24FN3O5
M.Wt: 501.51
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/1/310
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO
Storage: Store at +4℃
Purity: >98%
Chemical Name: