Product Name: DAPT (GSI-IX)
Subtitle: γ-secretase inhibitor,potent and specific
Biological Activity: Biological Activity of DAPT (GSI-IX)Inhibitor of γ-secretase; causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures (IC50 values are 115 and 200 nM for total Aβ and Aβ42 respectively) and in brain extract, cerebrospinal fluid
SMLES: CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
CAS NO: 474972
Standard In CHIKey: Sirtuin inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H26F2N2O4
M.Wt: 432.46
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/268/1/311
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO
Storage: Store at +4℃
Purity: >98%
Chemical Name: N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester