Product Name: Dabrafenib (GSK2118436)
Subtitle: Inhibitor of BRAF(V600) mutants
Biological Activity: Biological Activity of Dabrafenib (GSK2118436)Description Dabrafenib (GSK2118436) is a inhibitor of mutant BRAFV600 specific with an IC50 value of 0.8 nM. Targets B-Raf (V600E) B-Raf C-Raf IC50 0.8 nM 3.2 nM 5.0 nM
SMLES: CC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F
CAS NO: 144875-48-9
Standard In CHIKey: HSP inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H20F3N5O2S2
M.Wt: 519.56
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/2/536
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide