Product Name: Dapivirine (TMC120)
Subtitle: Nonnucleoside reverse transcriptase inhibitor
Biological Activity: Biological Activity of Dapivirine (TMC120)Description Dapivirine (TMC120) is a non-nucleoside inhibitor of HIV reverse transcriptase with an IC50 vaule of 24 nM. Targets HIV reverse transcriptase IC50 24 nM
SMLES: CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C
CAS NO: 146368-14-1
Standard In CHIKey: ILAYIAGXTHKHNT-UHFFFAOYSA-NIKK inhibitors
Standard InChI: InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25)
Typrof Compound:
Appearance:
Formula: C20H19N5
M.Wt: 329.4
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/256/2/634
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 4-[[4-(2,4,6-trimethylanilino)pyrimidin-2-yl]amino]benzonitrile