Product Name: Dovitinib (TKI-258, CHIR-258)
Subtitle: Multitargeted RTK inhibitor
Biological Activity: Biological Activity of Dovitinib (TKI-258, CHIR-258)Description Dovitinib is a multitargeted inhibitor of RTK with IC50 values of 1 nM, 2 nM and 8 nM for FLT3, c-Kit and FGFR1, respectively. Targets FLT3 c-Kit FGFR1 VEGFR3/FLT4 FGFR3 VEGFR1/FL
SMLES: CN1CCN(CC1)C2=CC3=C(C=C2)NC(=C4C(=C5C(=NC4=O)C=CC=C5F)N)N3
CAS NO: 501437-28-1
Standard In CHIKey: Thrombopoietin Receptor inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C21H21FN6O
M.Wt: 392.43
General Tips: for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/1/211
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: (3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one