Product Name: GDC-0068 (RG7440)
Subtitle: Pan-AKT inhibitor,highly selective
Biological Activity: Biological Activity of GDC-0068 (RG7440)Description Ipatasertib (GDC-0068) is a highly selective inhibitor of Akt for Akt1/2/3 with IC50 of 5 nM/18 nM/8 nM, 620-fold selectivity over PKA. Targets Akt1 Akt2 Akt3 IC50 5 nM 18 nM 8 nM
SMLES: C[C@@H]1C[C@H](c2c1c(ncn2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)c4ccc(cc4)Cl)O
CAS NO: 1808011-22-4
Standard In CHIKey: Drug-Linker Conjugates for ADC inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C24H32ClN5O2
M.Wt: 458
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/257/1/466
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: Ipatasertib