Product Name: GDC-0449 (Vismodegib)
Subtitle: Hedgehog antagonist,potent and selective
Biological Activity: Biological Activity of GDC-0449 (Vismodegib)Description Vismodegib (GDC-0449) is a potent, novel and specific inhibitor of hedgehog with IC50 of 3 nM and also inhibitor of P-gp with IC50 of 3.0 μM. Targets Hedgehog IC50 3 nM
SMLES: CS(=O)(=O)C1=CC(=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)C3=CC=CC=N3)Cl
CAS NO: 491833-29-5
Standard In CHIKey: PAI-1 inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C19H14Cl2N2O3S
M.Wt: 421.3
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/2/759
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 2-chloro-N-(4-chloro-3-pyridin-2-ylphenyl)-4-methylsulfonylbenzamide