Product Name: GDC-0941
Subtitle: PI3K inhibitor,potent and selective
Biological Activity: Biological Activity of GDC-0941Description GDC-0941 is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). Targets PI3Kα PI3Kβ PI3Kδ PI3Kγ IC50 3 nM 33 nM 3 nM 75 nM
SMLES: CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6
CAS NO: 1672665-49-4
Standard In CHIKey: ROCK inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C23H27N7O3S2
M.Wt: 513.64
General Tips: for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/257/2/727
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)methyl]thieno[3,2-d]pyrimidin-4-yl]morpholine