Product Name: Ki8751
Subtitle: VEGFR-2 inhibitor,potent and selective
Biological Activity: Biological Activity of Ki8751Potent, selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0.9 nM). Displays some inhibitory activity towards c-Kit, PDGFRα and FGFR-2 (IC50 values range from 40 to 170 nM) but is highly selective over other receptor
SMLES: COC1=CC2=C(C=CN=C2C=C1OC)OC3=CC(=C(C=C3)NC(=O)NC4=C(C=C(C=C4)F)F)F
CAS NO: 50-76-0
Standard In CHIKey: Salt-inducible Kinase SIK) inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C24H18F3N3O4
M.Wt: 469.41
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/1/190
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO
Storage: Store at +4℃
Purity: >98%
Chemical Name: N-(2,4-Difluorophenyl)-N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]-2-fluorophenyl]urea