Product Name: LGX818
Subtitle: RAF inhibitor,potent and selective
Biological Activity: Biological Activity of LGX818Description Encorafenib (LGX818) is a highly potent inhibitor of RAF with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. Targets B-RAF(V600E) IC50
SMLES: CC(C)N1C=C(C(=N1)C2=CC(=CC(=C2F)NS(=O)(=O)C)Cl)C3=NC(=NC=C3)NCC(C)NC(=O)OC
CAS NO: 1005342-46-0
Standard In CHIKey: DNA-PK inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C22H27ClFN7O4S
M.Wt: 540.01
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/2/491
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate