Product Name: Macbecin I
Subtitle:
Biological Activity: Biological Activity of Macbecin IAnsamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client
SMLES: O=C(C(NC1=O)=C2)C([C@@H]([C@@H](C)C[C@H]([C@H]([C@H](C)/C=C(C)/[C@H]([C@H](/C=CC=C1/C)C)OC(N)=O)OC)OC)OC)=CC2=O
CAS NO: 61281-38-7
Standard In CHIKey: PLTGBUPHJAKFMA-HXUNTIRESA-NBMX Kinase inhibitors
Standard InChI: InChI=1S/C30H42N2O8/c1-16-10-9-11-17(2)29(35)32-23-15-21(33)14-22(25(23)34)27(38-7)20(5)13-24(37-6)28(39-8)19(4)12-18(3)26(16)40-30(31)36/h9-12,14-16,19-20,24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b10-9-,17-11+,18-12+/t16-,19+,20-,24?,26?,27+,28-/m0/s1
Typrof Compound:
Appearance:
Formula: C30H42N2O8
M.Wt: 558.67
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/271/3/1409
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO
Storage: Desiccate at -20℃
Purity: >98%
Chemical Name: (15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin