Product Name: Neratinib (HKI-272)
Subtitle: HER2/EGFR inhibitor,potent and irreversible
Biological Activity: Biological Activity of Neratinib (HKI-272)Description Neratinib (HKI-272) is a highly selective inhibitor of HER2 and EGFR with IC50 of 59 nM and 92 nM, respectively. Targets HER2 EGFR IC50 59 nM 92 nM
SMLES: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C
CAS NO: 1009820-21-6
Standard In CHIKey: Others inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C30H29ClN6O3
M.Wt: 557.04
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/254/3/872
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Limited solubility
Storage:
Purity: >98%
Chemical Name: (E)-N-[4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-3-cyano-7-ethoxyquinolin-6-yl]-4-(dimethylamino)but-2-enamide