Product Name: PF-5274857
Subtitle: Smo antagonist,potent and selective
Biological Activity: Biological Activity of PF-5274857Description PF-5274857 is a potent and selective antagonist of Smoothened (Smo) with IC50 and Ki values of 5.8 nM and 4.6 nM, respectively. Targets Smoothened IC50 5.8 nM (Ki=4.6 nM)
SMLES: CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CCS(=O)(=O)C)C
CAS NO: 1423715-09-6
Standard In CHIKey: Tryptophan Hydroxylase inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C20H25ClN4O3S
M.Wt: 436.96
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/2/861
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 1-[4-[5-chloro-4-(3,5-dimethylpyridin-2-yl)pyridin-2-yl]piperazin-1-yl]-3-methylsulfonylpropan-1-one