Product Name: Pimasertib (AS-703026)
Subtitle: MEK1/2 inhibitor
Biological Activity: Biological Activity of Pimasertib (AS-703026)Description Pimasertib (AS-703026) is a highly selective, potent, ATP non-competitive allosteric inhibitor of MEK1/2 with IC50 values of 5 nM-2 μM in human multiple myeloma (MM) cell lines. Targets MEK1/
SMLES: C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NCC(CO)O
CAS NO: 141758-74-9
Standard In CHIKey: Drug-Linker Conjugates for ADC inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C15H15FIN3O3
M.Wt: 431.2
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/1/364
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-[(2S)-2,3-dihydroxypropyl]-3-(2-fluoro-4-iodoanilino)pyridine-4-carboxamide