Product Name: Pyrimethamine
Subtitle: DHFR inhibitor
Biological Activity: Biological Activity of PyrimethaminePotent inhibitor of multidrug and toxin extrusion (MATE) transporters (Ki values are 46 and 77 nM for human MATE2-K-HEK293 and MATE1-HEK293 cells respectively). Also inhibits dihydrofolate reductase (DHFR) and STAT3. De
SMLES: CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
CAS NO: 304462-19-9
Standard In CHIKey: WKSAUQYGYAYLPV-UHFFFAOYSA-NiGluR inhibitors
Standard InChI: InChI=1S/C12H13ClN4/c1-2-9-10(11(14)17-12(15)16-9)7-3-5-8(13)6-4-7/h3-6H,2H2,1H3,(H4,14,15,16,17)
Typrof Compound:
Appearance:
Formula: C12H13ClN4
M.Wt: 248.71
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/256/1/127
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage: Store at RT
Purity: >98%
Chemical Name: 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine