Product Name: (R)-Crizotinib
Subtitle: C-MET/ALK inhibitor,potent and ATP-competitve
Biological Activity: Biological Activity of (R)-CrizotinibPotent inhibitor of c-MET and anaplastic lymphoma kinase (ALK) (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple
SMLES: C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
CAS NO: 1094-61-7
Standard In CHIKey: BCRP inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C21H22Cl2FN5O
M.Wt: 450.34
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/1/323
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble to 10 mM in DMSO and to 100 mM in 2eq.HCl
Storage: Store at +4℃
Purity: >98%
Chemical Name: