Product Name: TAK-733
Subtitle: MEK allosteric site inhibitor
Biological Activity: Biological Activity of TAK-733Description TAK-733 is a potent and selective inhibitor of MEK allosteric site for MEK1 with an IC50 value of 3.2 nM. Targets MEK1 IC50 3.2 nM
SMLES: CN1C2=C(C(=C(C1=O)F)NC3=C(C=C(C=C3)I)F)C(=O)N(C=N2)CC(CO)O
CAS NO: 1160295-21-5
Standard In CHIKey: IRE1 inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C17H15F2IN4O4
M.Wt: 504.23
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/2/541
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-(2-fluoro-4-iodoanilino)-8-methylpyrido[2,3-d]pyrimidine-4,7-dione

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