Product Name: Tivozanib (AV-951)
Subtitle: VEGFR inhibitor,potent and selective
Biological Activity: Biological Activity of Tivozanib (AV-951)Description Tivozanib is an inhibitor of tyrosine kinase with IC50 value of 160 pM for VEGFR-2. Targets VEGFR-2 IC50 160 pM
SMLES: CC1=CC(=NO1)NC(=O)NC2=C(C=C(C=C2)OC3=C4C=C(C(=CC4=NC=C3)OC)OC)Cl
CAS NO: 700874-72-2
Standard In CHIKey: EGFR inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C22H19ClN4O5
M.Wt: 454.86
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/259/1/228
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea