Product Name: Trametinib (GSK1120212)
Subtitle: MEK1 and MEK2 inhibitor, potent and selective
Biological Activity: Biological Activity of Trametinib (GSK1120212)Description Trametinib (GSK1120212) is a highly specific and potent inhibitor of MEK1/2 with IC50 of 0.92 nM/1.8 nM. Targets MEK1 MEK2 IC50 0.92 nM 1.8 nM
SMLES: Cc1c2c(c(n(c1=O)C)Nc3ccc(cc3F)I)c(=O)n(c(=O)n2c4cccc(c4)NC(=O)C)C5CC5
CAS NO: 1386874-06-1
Standard In CHIKey: Natural Products inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C26H23FIN5O4
M.Wt: 615.39
General Tips: for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.PubMed ID:http://jpet.aspetjournals.org/content/255/1/187
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: Trametinib