Product Name: WZ4002
Subtitle: Mutant-selective EGFR inhibitor(L858R,T790M), irreversible and potent
Biological Activity: Biological Activity of WZ4002Description WZ4002 is a novel, mutant-selective inhibitor of EGFR for EGFR(L858R)/(T790M) with IC50 of 2 nM/8 nM. Targets EGFRL858R EGFRL858R/T790M IC50 2 nM 8 nM
SMLES: CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)OC4=CC=CC(=C4)NC(=O)C=C)Cl)OC
CAS NO: 1222998-36-8
Standard In CHIKey: Gli inhibitors
Standard InChI:
Typrof Compound:
Appearance:
Formula: C25H27ClN6O3
M.Wt: 494.18
General Tips: For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.PubMed ID:http://jpet.aspetjournals.org/content/254/3/1045
Shipping Condition: Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.
Solubility: Soluble in DMSO > 10 mM
Storage:
Purity: >98%
Chemical Name: N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide