Product Name: ZaurategrastSubtitle: Integrin inhibitorBiological Activity: SMLES: C1CCC2(CC1)C(=C(C2=O)Br)NC(CC3=CC=C(C=C3)NC4=NC=CC5=C4C=NC=C5)C(=O)OCAS NO: 119413-54-6Standard In CHIKey: EBI2_GPR183 inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C26H25BrN4O3M.Wt: 521.42General Tips: For obtaining a higher solubility , please warm…
Product Name: FirategrastSubtitle: α4β1/α4β7 integrin antagonistBiological Activity: Biological Activity of FirategrastDescription Firategrast is an orally bioavailable antagonist of alpha4 beta1/alpha4 beta7 integrin. Targets α4β1/α4β7 integrin IC50SMLES: CCOCC1=CC(=C(C(=C1)OC)C2=CC=C(C=C2)CC(C(=O)O)NC(=O)C3=C(C=CC=C3F)F)OCCAS NO: 478182-28-4Standard In…
Product Name: CGI-1746Subtitle: Btk inhibitorBiological Activity: Biological Activity of CGI-1746Description CGI1746 is a potent and highly selective small-molecule inhibitor of the Btk with IC50 value of 1.9 nM. Targets Btk…
Product Name: AVL-292Subtitle: Btk inhibitorBiological Activity: Biological Activity of AVL-292Description AVL-292 is a highly selective, orally active small-molecule inhibitor of Btk with IC50 value of 0.5 nM. Targets Btk IC50…
Product Name: PCI-32765 (Ibrutinib)Subtitle: Brutons tyrosine kinase (BTK) inhibitorBiological Activity: Biological Activity of PCI-32765 (Ibrutinib)Description Ibrutinib is a potent and highly selective inhibitor of Btk with IC50 of 0.5 nM,…
Product Name: PRIMA-1Subtitle: BAX inhibitorBiological Activity: Biological Activity of PRIMA-1Selectively restores mutant p53 activity in tumor cells via activation of Bax and PUMA. Induces apoptosis and inhibits growth of human…
Product Name: Pifithrin-μSubtitle: Inhibitor of p53 binding and anti-apoptoticBiological Activity: Biological Activity of Pifithrin-μInhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Displays no…
Product Name: PhiKan 083Subtitle: p53 stabilizerBiological Activity: Biological Activity of PhiKan 083p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction…
Product Name: NSC 146109 hydrochlorideSubtitle: Antitumor agent,p53-dependent transcription activatorBiological Activity: Biological Activity of NSC 146109 hydrochlorideCell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription. Increases levels of endogenous p53 in tumor…
Product Name: MIRA-1Subtitle: Restorer of wild-type p53 conformation/cellular functionBiological Activity: Biological Activity of MIRA-1Restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21,…