Umulate in tumor through enhanced permeability and retention effect (EPR) [17,18]. In the similar time, the organic linker can be in addition functionalized for targeting cancer therapy [19,20]. Moreover, the great dispersibility and biocompatibility of precise MOFs can ensure the biosafety of targeting therapy in vivo [21]. Adjustable composition benefits in controlled synthesis with various morphology, size, and chemical properties, making MOF itself a nanodrug for multimodal imaging and therapy by picking out proper metal nodes and organic ligands [22,23]. In addition, the porous and orderedBiosensors 2021, 11, 299. https://doi.org/10.3390/bioshttps://www.mdpi.com/journal/biosensorsBiosensors 2021, 11, xBiosensors 2021, 11,two of2 ofmaking MOF itself a nanodrug for multimodal imaging and therapy by deciding upon appro priate metal nodes and organic ligands [22,23]. Additionally, the porous and ordered struc ture as well as the high ratio surface places are suitable for efficient loading of different cargos for structure along with the higher ratio surface regions are appropriate for efficient loading of different cargos multimodal imaging and therapy [248]. MOFbased nanomaterials were applied to flu for multimodal imaging and therapy [248]. MOFbased nanomaterials have been applied to orescence imaging (FL) [292], photoacoustic imaging (PAI) [33], magnetic resonance im fluorescence imaging (FL) [292], photoacoustic imaging (PAI) [33], magnetic resonance aging (MRI) [346], computed Recombinant?Proteins FGF-1 Protein tomography imaging (CTI) [379], photothermal imag imaging (MRI) [346], computed tomography imaging (CTI) [379], photothermal imaging (PTI) [40,41] and positron emission tomography (PET) imaging [425]. It is worth ing (PTI) [40,41] and positron emission tomography (PET) imaging [425]. It truly is worth mentioning that multimodal imaging [462] is useful for tumor diagnosis and accu mentioning that multimodal imaging [462] is beneficial for tumor diagnosis and correct price position. MOFbased heterogeneous hybridization may perhaps serve as an effective strategy position. MOFbased heterogeneous hybridization may well serve as an efficient methodology ology for multimodal imaging and synergistic therapy. It integrates the advantages of for multimodal imaging and synergistic therapy. It integrates the positive aspects of numerous numerous components and the hybrid materialsmaterials with entire new physicochemical components and endues endues the hybrid with entire new physicochemical properties, properties, realizing theranostic nanoplatforms by means of multimode imagingguided realizing theranostic nanoplatforms through multimode imagingguided therapy. Within this therapy. the this overview, the biodegradable MOFs as FGF-8c Protein E. coli nanodrugs and nanocarriers forand overview, In development of improvement of biodegradable MOFs as nanodrugs multimodal imaging and therapy in recent years might be summarized and discussed, as shown nanocarriers for multimodal imaging and therapy in recent years will be summarized and in Figure 1, and the prospects and challenges of MOFs in multimodal synergistic treatment discussed, as shown in Figure 1, as well as the prospects and challenges of MOFs in multimodal may also be explored for promising clinic/biomedical applications. synergistic treatment will also be explored for promising clinic/biomedical applications.Figure 1. Schematic diagram of MOFs as nanodrugs and nanocarriers for multimodal theranostic, Figure 1. Schematic diagram of MOFs as nanodrugs and nanocarrier.