L deficits, or any drug intake. Household history of alcoholism, but not hypertension was noted in his father and brother. On admission, vital parameters showed marginal alcohol withdrawal sympathetic activity with pulse rate of 96 beats/min and BP of 140/90 mm of Hg. His basic physical plus the systemic examination revealed no other abnormal findings, except for fine tremors of both hands and mild hepatomegaly. RSPO1/R-spondin-1 Protein supplier patient had preoccupations with alcohol, anxious mood with preserved cognitions, and grade4 insight. Just after alcohol detoxification, his BP had stabilized to 120/84 mm of Hg on day8 of admission. Electrocardiograph revealed no abnormalities. Hematological and biochemical investigations which include comprehensive blood count, blood glucose (105 mg/dl), blood urea (25 mg/dl), and serum creatinine (1.0 mg/dl) were inside regular limits. Liver function tests had been normal except for elevated liver CFHR3 Protein site enzymes (gammaglutamyl transferase 96 units/L; serum glutamic oxaloacetic transaminase 120 units/L; serum glutamic pyruvic transaminase 56 units/L). His ultrasound abdomen showed mildly enlarged liver with grade2 fatty infiltration. Thinking of frequent relapses, patient, and spouse were explained about the nature of illness, and its many treatment modalities obtainable including DSF. Written informed consent for DSF therapy was taken and a dose of 500 mg/day was initiated. Patient was discharged with DSF (500 mg/day), and multivitamin supplementation. At discharge, his crucial parameters have been stable with pulse of 86 beats/min, and BP of 130/80 mm of Hg. Compliance with medicines was ensured and supervised by his spouse. A fortnight later, patient complained of gradual onset occipital headache and giddiness with pulse price of 86 bpm and BP of 146/100 mm of Hg. Life style modifications and dietary measures together with above prescribed medicines were advised. On week4 of DSF therapy, his complaints of headache, giddiness worsened, and BP improved to 170/110 mm of Hg. In view of recent inclusion of DSF, using the absence of prior medical illnesses or drug history contributing to hypertension, possibility of drug induced (DSF) hypertension was suspected. Subsequently, DSF was lowered to 250 mg/ day and BP lowered to 150/96 mm of Hg a week later. DSF was further decreased to 125 mg/day following this observation and antihypertensive agents like telmisartan 40 mg and hydrochlorothiazide 12.5 mg/daywere also initiated around the physician’s suggestions. A month later (week8), patient reported with enhanced giddiness and physical fatigue with BP of 90/60 mm of Hg despite abstinent. Antihypertensive agents were withdrawn and DSF was discontinued entirely. Fortnight later (week10), patient had reached his premorbid levels of BP to 110/70 mm of Hg. Psycho education about healthcare illness, life style modifications for instance normal workout routines and dietary measures had been advised. Six months later, patient had maintained full abstinence from alcohol also as tobacco, and his BP was 130/80 mm of Hg [Figure 1].DISCuSSIONDSF, an alcohol deterring agent which is reasonably nontoxic substance when administered alone, markedly alters the intermediary metabolism of alcohol. It acts by inhibiting aldehyde dehydrogenase, alcohol dehydrogenase and dopamine betahydroxylase (DBH).[9] DSF in conjunction with its two metabolites, diethyldithiocarbamate, and carbon disulphide inhibit DBH activity, a norepinephrine (NE) biosynthetic enzyme, which commonly catalyzes the formation of NE from dopamin.