Tive cardiac surgery with CPBPro-MMP-2, MMP-2, Pro-MMP-9, MMP-cardiac troponin TMMP-2 and MMP-9 activity in remote ischemic preconditioningmediated cardioprotection Alterations in MMP-9 following CPB. To investigate the association between MMP-9 and PaO2 /FiO2 Distinction in levels of MMP-3, MMP-8, MMP-9, TIMP-1, and LCN-2 with or with no continuous mechanical ventilation throughout CPB Modifications in serum and urine MMP-2 and MMP-9 following CPB. To analyze MMP-2 and MMP-9 as early biomarkers of AKI To evaluate the effect of MMPs and TIMPs on post-operative outcomes of patients with constrictive pericarditis undergoing pericardiectomyAfter CPB, pro-MMP2, MMP-2, pro-MMP-9, and MMP-9 were not distinctive in the general population. Optimistic correlation amongst MMP-2 and MMP-9 and cardiac troponin T.Lin, 2015 [20]Prospective observational NRCTPatients undergoing elective cardiac surgery with CPBMMP–MMP-9 levels enhanced 2, four, and six h after CPB begin, returning closely for the baseline at 24 h. MMP-9 levels at 4 and six h have been not correlated with prolonged CPB time and PaO2 /FiO2 .Beer, 2015 [21]Prospective observational NRCTPatients undergoing CABG with CPBMMP-3, MMP-8, MMP-LCN-MMP-8, MMP-9, and LCN-2 had been lower in the finish of surgery in ventilated individuals.McNair, 2021 [22]Prospective observational NRCTPatients undergoing elective cardiac surgery with CPBMMP-2, MMP-Serum creatinineSerum and urine levels of MMP-2 and MMP-9 were larger inside the AKI patients compared with non-AKI individuals. MMP-2 and MMP-9 enhanced earlier than serum creatinine in AKI individuals.Fang, 2022 [23]Retrospective observational NRCTPatients undergoing pericardiectomy with CPBMMP-1, MMP-2, MMP-9, TIMP–MMP-9 was linked with postoperative complications, with an optimal cutoff predicting value of 3.67.Gao, 2022 [6]Prospective RCTPatients undergoing elective CABG or valve replacement with CPBMMP-2, MMP-Syndecan-Changes in MMPs with doxycycline administrationMMP-2 and MMP-9 levels were decrease inside the doxycycline group than those in the manage group through CPB.three.1. Incorporated Studies Of your 15 studies included, 5 had been potential RCTs (n = 211) [6,7,16,18,19], and 1 was a retrospective observational study [23], whereas the remaining 9 were potential observational NRCTs [115,17,202]. All research included patients submitted to cardiac surgery with CPB, but some far better defined their population: seven studies enrolled sufferers undergoing CABG with CPB (n = 213) [7,114,16,21], one study incorporated sufferers submitted to off-pump or on-pump CABG [15], a single enrolled individuals submitted to pericardiectomy with CPB [23], and one incorporated patients undergoing to CABG or valve replacement with CPB [6].Biomolecules 2023, 13,6 ofMMP-9 was the metalloproteinase investigated in all trials.SPARC Protein web Seven trials studied MMP2 [6,7,11,12,14,19,23], and three papers studied MMP-8 [7,12,21].C-MPL Protein supplier MMP-1 was also studied in a single trial [23], MMP-3 was investigated in 1 paper [21], and MMP-7 was analyzed in a single trial [17], while MMP-13 was evaluated in 1 study [12].PMID:24580853 5 articles studied TIMP-1 [136,23], whilst just one particular paper evaluated TIMP-4 [11]. three.two. Excluded Research Five trials that met our inclusion criteria have been excluded right after evaluation with the complete manuscript (Table S3 of Supplementary Material). Four trials were excluded since they have been animal investigation [247]. One particular trial was excluded because it was an in vitro study along with the part of CPB was not investigated [28]. 3.3. Primary Findings The MMPs analyzed in cardiac surgery patients wit.