Name : Mouse Fc epsilon RI alpha/FCER1a Protein
Product Source :
Recombinant Mouse Fc epsilon RI alpha/FCER1a Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Ala24-Gln204.[Accession | P20489]
Molecular Weight :
The protein has a predicted MW of 47.7 kDa. Due to glycosylation, the protein migrates to 68-72 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse Fc epsilon RI alpha/FCER1a on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse Fc epsilon RI alpha/FCER1a is greater than 95% as determined by SEC-HPLC.
Background :
Known susceptibility genes to atopy and asthma have been identified by linkage or associations with clinical phenotypes, including total serum IgE levels. IgE-mediated sensitivity reactions require a high-affinity IgE receptor (FcepsilonRI), which immobilizes the immunoglobulin on the surface of the effector cells, mostly mast cells and basophils. Similarly to the previously investigated beta subunit of the receptor, FCER1A is a good candidate for a quantitative trait locus (QTL) in allergic diseases, and appears to participate in the systemic regulation of IgE levels.
Synonyms :
Fc-epsilon RI-alpha; FcERI; FCER1A; FCE1A
References & Citations :
(1) Sanak M, Potaczek DP, Nizankowska-Mogilnicka E, Szczeklik A. Genetic variability of the high-affinity IgE receptor alpha subunit (Fc epsilon RI alpha) is related to total serum IgE levels in allergic subjects. Allergol Int. 2007 Dec;56(4):397-401. doi: 10.2332/allergolint.R-07-145. Epub 2007 Nov 1. PMID: 17965580.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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