Name : Mouse GIP Protein

Product Source :
Recombinant Mouse GIP Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Glu22-Gln85.[Accession | P48756]

Molecular Weight :
The protein has a predicted MW of 34.3 kDa. Due to glycosylation, the protein migrates to 40-45 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Mouse GIP on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse GIP is greater than 95% as determined by SEC-HPLC.

Background :
The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial. Initial interest in the therapeutic use of GIP was dampened by evidence that its insulinotropic activity was reduced in type 2 diabetes and by reports that it increased glucagon secretion and adipose deposition in non-diabetic individuals.

Synonyms :
GIP; Incretin

References & Citations :
(1) Bailey CJ. GIP analogues and the treatment of obesity-diabetes. Peptides. 2020 Mar;125:170202. doi: 10.1016/j.peptides.2019.170202. Epub 2019 Nov 19. PMID: 31756366.

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