Name : Rhesus macaque gp130/CD130/IL-6 R beta Protein
Product Source :
Recombinant Rhesus macaque gp130/CD130/IL-6 R beta Protein is expressed from HEK293 with His tag at the C-Terminus.; It contains Glu47-Ala644.[Accession | F7FXB6]
Molecular Weight :
The protein has a predicted MW of 69.09 kDa. Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3-6 months after reconstitution.; 2-8°C for 2-7 days after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Rhesus macaque gp130 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Rhesus macaque gp130 is greater than 95% as determined by SEC-HPLC.
Background :
gp130 is a common signal transducing component of the functional receptor complexes for the interleukin (IL)-6 family of cytokines, ie, IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1. These cytokines exhibit pleiotropic biological activities in, for instance, immune, hematopoietic, and neural systems, and function in a redundant manner owing to the shared usage of gp130.
Synonyms :
gp130; CD130; IL-6 R beta; IL-6R-beta; IL-6RB; CDw130; IL6ST
References & Citations :
Nakashima K, Taga T. gp130 and the IL-6 family of cytokines: signaling mechanisms and thrombopoietic activities. Semin Hematol. 1998 Jul;35(3):210-21. PMID: 9685167.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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