Name : Human Azurocidin/CAP37/AZU1/HBP Protein
Product Source :
Recombinant Human Azurocidin/CAP37/AZU1 /HBP Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Ile27-Pro250.[Accession | P20160]
Molecular Weight :
The protein has a predicted MW of 25.3 kDa. Due to glycosylation, the protein migrates to 38-50 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22μm filtered solution in 20mM PB,500mM NaCl (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human Azurocidin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human Azurocidin is greater than 95% as determined by SEC-HPLC.
Background :
Heparin-binding protein (HBP), also known as cationic antimicrobial protein 37 (CAP37) and Azurocidin, is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3). This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Synonyms :
CAP37; AZU; AZU1; Azurocidin; HBP; AZAMP; HUMAZUR; NAZC; azurocidin 1
References & Citations :
(1)Lehrer, Robert I. Encyclopedia of Immunology || Microbicidal Mechanisms, Oxygen-Independent[J]. encyclopedia of immunology, 1998:1719-1725.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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