Name : Mouse HPN Protein
Product Source :
Recombinant Mouse HPN Protein is expressed from HEK293 with His tag at the C-Terminus. It contains Thr60-Pro436.[Accession | O35453-1]
Molecular Weight :
The protein has a predicted MW of 42.2 kDa. Due to the protein cleaved into the following two chains, so it migrates to 18-22 kDa and 30 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in 20mM NaAc,150mM NaCl (pH 5.0). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 20mM NaAc,150mM NaCl (pH 5.0).
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse HPN on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse HPN is greater than 95% as determined by SEC-HPLC.
Background :
Home parenteral nutrition (HPN) has been proposed as the treatment of choice in patients suffering from intestinal failure (IF) and has been claimed to improve survival and quality of life either in patients with benign disorders or even in those with malignancies. HPN seems to have beneficial effect but it should be considered with caution by the physicians who should take into account the indications of each patient to receive parenteral nutrition, the underlying disease and prognosis and the access of each patient to home care services.
Synonyms :
Serine protease hepsin; TMPRSS1; Hepsin
References & Citations :
(1) Spiliotis J, Kopanakis N, Prodromidou A, Terras A, Polichronaki A, Koutikova C, Gogou A, Sidera C, Efstathiou E. Survival and nutritional factors on home parenteral nutrition (HPN): Our initial experience. J BUON. 2018 Jan-Feb;23(1):244-247. PMID: 29552791.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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