Name : Mouse PTN Protein
Product Source :
Recombinant Mouse PTN Protein is expressed from HEK293 with hFc tag at the N-Terminus. It contains Gly33-Asp168.[Accession | P63089]
Molecular Weight :
The protein has a predicted MW of 42.6 kDa. Due to glycosylation, the protein migrates to 49-52 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Mouse PTN on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Mouse PTN is greater than 95% as determined by SEC-HPLC.
Background :
Pleiotrophin (PTN) is a secreted cell cytokine associated with the extracellular matrix and acts as a growth factor. PTN is mainly expressed in neuroectodermal and mesodermal tissues, indicating its effect in neuron migration and epithelium-mesenchyme interactions. Whereas PTN is associated with some neurodegenerative diseases and has modulating effects on them.
Synonyms :
Pleiotrophin; PTN; HBBM; HBGF-8; HB-GAM; HBNF; OSF-1; HARP; HBGF8; NEGF1HBGF-8; HBBN; OSF
References & Citations :
(1) Lv Y, Sun Y, Dai D, Luan ZL, Lu HY, Li CJ, Luo YY. Positive association between PTN polymorphisms and schizophrenia in Northeast Chinese Han population. Psychiatr Genet. 2020 Oct;30(5):141-149. doi: 10.1097/YPG.0000000000000262. PMID: 32868733.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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