Name : Human TENM2 Protein
Product Source :
Recombinant Human TENM2 Protein is expressed from HEK293 with His tag at the N-Terminus. It contains Gly401-Asn841.[Accession | Q9NT68-1]
Molecular Weight :
The protein has a predicted MW of 48.48 kDa. The protein cleaved to 55-65 kDa, 38-43 kDa and 25-30 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 90% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS, 2mM DTT (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human TENM2 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.
Background :
Teneurin-2 is a member of a novel family of transmembrane proteins characterized to date in fish, birds, mammals, and Drosophila (e.g., the pair-rule gene product Ten-m). Teneurin-2, a vertebrate homologue of the Drosophila pair-rule gene ten-m/odz, is revealed to be a membrane-bound transcription regulator. In the nucleus, the intracellular domain of teneurin-2 colocalizes with promyelocytic leukemia (PML) protein in nuclear bodies implicated in transcription control.
Synonyms :
Teneurin-2; Ten-2; Tenascin-M2; Ten-m2; KIAA1127; ODZ2; TNM2
References & Citations :
(1) Bagutti C, Forro G, Ferralli J, Rubin B, Chiquet-Ehrismann R. The intracellular domain of teneurin-2 has a nuclear function and represses zic-1-mediated transcription. J Cell Sci. 2003 Jul 15;116(Pt 14):2957-66. doi: 10.1242/jcs.00603. Epub 2003 Jun 3. PMID: 12783990.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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