Name : Human CEACAM-6/CD66c Protein

Product Source :
Recombinant Human CEACAM-6/CD66c Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Lys35-Gly320.[Accession | P40199]

Molecular Weight :
The protein has a predicted MW of 34.1 kDa. Due to glycosylation, the protein migrates to 55-75 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt. -80°C for 3-6 months after reconstitution. 2-8°C for 2-7 days after reconstitution. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Tris-Bis PAGE Human CEACAM-6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of Human CEACAM-6 is greater than 95% as determined by SEC-HPLC. SPR Data Human CEACAM-8, His Tag immobilized on CM5 Chip can bind Human CEACAM-6, His Tag with an affinity constant of 4.59 μM as determined in SPR assay (Biacore T200).

Background :
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) belongs to the human carcino-embryonic antigen (CEA) family. Numerous lines of studies have indicated that altered expression of CEACAM6 may have a role in carcinogenesis and development.

Synonyms :
CEACAM6; CD66c; CEAL; NCA; CEA

References & Citations :
(1)harma N, Srivastava S, Kern F, et al. CEACAM 6, a novel marker for the diagnosis of Barrett’s esophagus. Dis Esophagus. 2017;30(7):1-5. doi:10.1093/dote/dox026

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