Name : Human CCL8 Protein

Product Source :
Recombinant Human CCL8 Protein is expressed from E.coli without tag. It contains Gln24-Pro99.[Accession | P80075]

Molecular Weight :
The protein has a predicted MW of 8.91 kDa. The protein migrates to 12-14 kDa based on Tris-Bis PAGE result.

Endotoxin Level :
Less than 1EU per μg by the LAL method.

Purity :
> 95% as determined by Tris-Bis PAGE

Formulation :
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.-80°C for 3-6 months after reconstitution.2-8°C for 2-7 days after reconstitution.Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Product Concentration :
Human CCL8 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Background :
C-C motif Chemokine ligand 8 (CCL8) has been found in diseases’ pathogenesis. Exogenous CCL8 enhanced the proliferative and migration potential of LE cells and their motility in the environment with its stable concentration.of all the examined factors, chemokine CCL8 participates in the establishment of a proper environment for embryo implantation.

Synonyms :
HC14; MCP-2; MCP2; SCYA10; SCYA8

References & Citations :
(1)Dai S, Zhang J, Xu Z. Silencing CCL8 inhibited the proliferation and migration of PDGF-BB-stimulated human aortic smooth muscle cells. Biosci Biotechnol Biochem. 2020 Aug;84(8):1585-1593. doi: 10.1080/09168451.2020.1762160. Epub 2020 May 20. PMID: 32432500.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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