Product Name: Varlitinib (ARRY334543)Subtitle: ErbB inhibitorBiological Activity: Biological Activity of Varlitinib (ARRY334543)Description Varlitinib is a selective and potent inhibitor of ErbB1(EGFR) and ErbB2(HER2) with IC50 values of 7 nM and…
Product Name: AG-1478Subtitle: EGFR inhibitor,potent and selectiveBiological Activity: Biological Activity of AG-1478Description AG-1478 (Tyrphostin AG-1478) is a selective inhibitor of EGFR with an IC50 values of 3 nM. Targets EGFR…
Product Name: NSC 74859Subtitle: Stat3 inhibitorBiological Activity: Biological Activity of NSC 74859Selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and…
Product Name: Neratinib (HKI-272)Subtitle: HER2/EGFR inhibitor,potent and irreversibleBiological Activity: Biological Activity of Neratinib (HKI-272)Description Neratinib (HKI-272) is a highly selective inhibitor of HER2 and EGFR with IC50 of 59 nM…
Product Name: Dacomitinib (PF299804, PF299)Subtitle: HER inhibitorBiological Activity: Biological Activity of Dacomitinib (PF299804, PF299)Description PF-299804 is a potent, irreversible inhibitor of ErbB for EGFR with IC50 of 6 nM. Targets…
Product Name: Afatinib (BIBW2992)Subtitle: Irreversible EGFR/HER2 inhibitorBiological Activity: Biological Activity of Afatinib (BIBW2992)Description Afatinib (BIBW2992) is an irreversible inhibitor of EGFR/HER2 for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 with IC50 of…
Product Name: Erlotinib HydrochlorideSubtitle: Selective EGFR inhibitorBiological Activity: Biological Activity of Erlotinib HydrochlorideDescription Erlotinib HCl (OSI-744) is an inhibitor of EGFR with IC50 of 2 nM, >1000-fold more sensitive for…
Product Name: LapatinibSubtitle: EGFR/HER2 inhibitor,potent,selective and reversibleBiological Activity: Biological Activity of LapatinibDescription Lapatinib is a potent inhibitor of EGFR and ErbB2 with IC50 of 10.8 and 9.2 nM, respectively. Targets…
Product Name: PD153035 hydrochlorideSubtitle: Potent EGFR inhibitorBiological Activity: Biological Activity of PD153035 hydrochlorideDescription PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and…
Product Name: Compound 56Subtitle: REGFR inhibitorBiological Activity: Biological Activity of Compound 56Description Compound 56 is a cell-permeable, reversible, and ATP-competitive inhibitor of tyrosine kinase activity of EGFR. Targets EGFR IC50SMLES:…