PD 146176
Product Name: PD 146176Subtitle: Biological Activity: Biological Activity of PD 146176Specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM) that has no demonstrable effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50…
RWJ 21757
Product Name: RWJ 21757Subtitle: Biological Activity: Biological Activity of RWJ 21757Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various…
MK 886
Product Name: MK 886Subtitle: Biological Activity: Biological Activity of MK 886An inhibitor of leukotriene biosynthesis (IC50 = 3 nM in human polymorphonuclear leukocytes). Acts by inhibiting 5-lipoxygenase-activating protein (FLAP) (IC50…
BW-B 70C
Product Name: BW-B 70CSubtitle: 5-Lipoxygenase inhibitor,potent and selectiveBiological Activity: Biological Activity of BW-B 70CPotent, selective inhibitor of 5-lipoxygenase. Long half-life and high oral bioavailability in vivo.SMLES: FC1=CC=C(C=C1)OC2=CC(/C=C/(C)N(C(N)=O)O)=CC=C2CAS NO: 1286739-19-2Standard In…
Cyclosporin D
Product Name: Cyclosporin DSubtitle: An immunosuppressive agentBiological Activity: SMLES: C/C()=C()/C(C((N1C)()/C(O)=N(C(N(CC(N((/C(O)=N/(C(N((/C(O)=N/(/C(O)=N/(C(N((C(N((C(N((C1=O)()C(C)C)C)=O)()CC(C)C)C)=O)()CC(C)C)C)=O)()C)()C)()CC(C)C)C)=O)()C(C)C)()CC(CAS NO: 867160-71-2Standard In CHIKey: ZNVBEWJRWHNZMK-APUFIDQKSA-NIGF-1R inhibitorsStandard InChI: InChI=1S/C63H113N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)51(40(Typrof Compound: Appearance: Formula: C63H111N11O12M.Wt: 1214.62General Tips: For obtaining a higher solubility ,…
CU CPT 22
Product Name: CU CPT 22Subtitle: Biological Activity: Biological Activity of CU CPT 22Selective toll-like receptor 1/2 (TLR1/2) inhibitor (IC50 = 0.58 μM). Exhibits no activity at TLR2/TLR6, TLR3, TLR4 and…
CU CPT 4a
Product Name: CU CPT 4aSubtitle: Biological Activity: Biological Activity of CU CPT 4aSelective TLR3 inhibitor (IC50 = 3.44 μM in RAW 264.7 cells); suppresses downstream signaling pathways mediated by the…
Pam2CSK4
Product Name: Pam2CSK4Subtitle: Biological Activity: Biological Activity of Pam2CSK4Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.SMLES:…
Pam3CSK4
Product Name: Pam3CSK4Subtitle: Biological Activity: Biological Activity of Pam3CSK4Toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60…
Poly(I:C)
Product Name: Poly(I:C)Subtitle: Biological Activity: Biological Activity of Poly(I:C)Synthetic double-stranded RNA (dsRNA); Toll-like receptor 3 (TLR3) agonist. Aids generation of stable, mature dendritic cells. Transfection into NIT-1 β cells induces…