Name : FITC-Labeled Human FOLR1 Protein
Product Source :
Recombinant FITC-Labeled Human FOLR1 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus. It contains Arg25-Met233.[Accession | P15328]
Molecular Weight :
The protein has a predicted MW of 27.5 kDa. Due to glycosylation, the protein migrates to 37-47 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE> 95% as determined by HPLC
Formulation :
Supplied as 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution :
Storage and Stability :
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE FITC-Labeled Human FOLR1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. SEC-HPLC The purity of FITC-Labeled Human FOLR1 is greater than 95% as determined by SEC-HPLC. ELISA Data Immobilized FITC-Labeled Human FOLR1, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-FOLR1 Antibody, hFc Tag with the EC50 of 15.0ng/ml determined by ELISA.
Background :
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 – 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
Synonyms :
FR-alpha; FR alpha; FR α; FOLR; FOLR1; FBP; Folbp1; KB cells FBP; MOv18; Folate Receptor 1; Fbp1; Folate receptor alpha;
References & Citations :
(1)Anthony C , Bax H J , Josephs D H , et al. Targeting folate receptor alpha for cancer treatment[J]. Oncotarget, 2016, 7(32).
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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