Name : Human IL-23 P19/IL-23A Protein
Product Source :
Recombinant Human IL-23 P19/IL-23A Protein is expressed from HEK293 with hFc tag at the C-Terminus. It contains Arg20-Pro189.[Accession | Q9NPF7]
Molecular Weight :
The protein has a predicted MW of 45.43 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
Endotoxin Level :
Less than 1EU per μg by the LAL method.
Purity :
> 95% as determined by Tris-Bis PAGE
Formulation :
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution :
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage and Stability :
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3-6 months after reconstitution.; 2-8°C for 2-7 days after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Product Concentration :
Tris-Bis PAGE Human IL-23 P19 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Background :
IL-23 is a heterodimeric cytokine composed of a unique p19 subunit and a common p40 subunit is shared with IL-12. IL-23 promotes the inflammatory response by inducing the expansion of CD4(+) cells producing IL-17.
Synonyms :
IL-23 P19; IL-23A; IL-23-A; IL-23p19; IL23p19; SGRF
References & Citations :
Mise-Omata S, Kuroda E, Niikura J, Yamashita U, Obata Y, Doi TS. A proximal kappaB site in the IL-23 p19 promoter is responsible for RelA- and c-Rel-dependent transcription. J Immunol. 2007 Nov 15;179(10):6596-603. doi: 10.4049/jimmunol.179.10.6596. PMID: 17982049.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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