Losmapimod
Product Name: LosmapimodSubtitle: p38 MAPK inhibitor, orally activeBiological Activity: Biological Activity of LosmapimodDescription Losmapimod (GW856553X) is a selective, potent, and orally active inhibitor of p38 MAPK with a pKi values…
TCS JNK 5a
Product Name: TCS JNK 5aSubtitle: JNK2 and JNK3 inhibitorBiological Activity: Biological Activity of TCS JNK 5aSelective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for…
RO4987655
Product Name: RO4987655Subtitle: MEK inhibitorBiological Activity: SMLES: C1CC(=O)N(OC1)CC2=C(C(=C(C(=C2)C(=O)NOCCO)NC3=C(C=C(C=C3)I)F)F)FCAS NO: 1051375-16-6Standard In CHIKey: Microtubule_Tubulin inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C20H19F3IN3O5M.Wt: 565.28General Tips: For obtaining a higher solubility , please warm…
H 89 2HCl
Product Name: H 89 2HClSubtitle: Potent PKA inhibitorBiological Activity: Biological Activity of H 89 2HClProtein kinase A inhibitor that also inhibits several other kinases (IC50 values are 80, 120, 135,…
TAK-733
Product Name: TAK-733Subtitle: MEK allosteric site inhibitorBiological Activity: Biological Activity of TAK-733Description TAK-733 is a potent and selective inhibitor of MEK allosteric site for MEK1 with an IC50 value of…
Dabrafenib (GSK2118436)
Product Name: Dabrafenib (GSK2118436)Subtitle: Inhibitor of BRAF(V600) mutantsBiological Activity: Biological Activity of Dabrafenib (GSK2118436)Description Dabrafenib (GSK2118436) is a inhibitor of mutant BRAFV600 specific with an IC50 value of 0.8 nM.…
SB590885
Product Name: SB590885Subtitle: Potent B-Raf inhibitorBiological Activity: Biological Activity of SB590885Potent B-Raf inhibitor (Kd = 0.3 nM). Selective for B-Raf against 46 other kinases (Ki app values are 0.16 and…
GW5074
Product Name: GW5074Subtitle: C-Raf inhibitor,potent and selectiveBiological Activity: Biological Activity of GW5074Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over…
SB 203580 hydrochloride
Product Name: SB 203580 hydrochlorideSubtitle: Specific p38-MAPKs inhibitorBiological Activity: Biological Activity of SB 203580 hydrochlorideWater-soluble salt of SB 203580. Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50…
Refametinib
Product Name: RefametinibSubtitle: MEK 1/ MEK 2 inhibitorBiological Activity: Biological Activity of RefametinibDescription Refametinib (RDEA119, Bay 86-9766) is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2…