Product Name: GDC-0879Subtitle: B-Raf inhibitor,potent and selectiveBiological Activity: Biological Activity of GDC-0879Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified B-Raf V600E). Activity reduces phospho-ERK (pERK) levels (IC50…
Product Name: SP 600125Subtitle: JNK1/2/3 inhibitorBiological Activity: Biological Activity of SP 600125Selective JNK inhibitor. Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 – 90 nM) with negligible…
Product Name: XMD8-92Subtitle: BMK1/ERK5 inhibitor,highly selectiveBiological Activity: Biological Activity of XMD8-92ERK5 (BMK1) and BRD4 inhibitor (Kd values are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (Kd…
Product Name: XMD17-109Subtitle: ERK-5 inhibitorBiological Activity: Biological Activity of XMD17-109Potent and selective ERK5 inhibitor; inhibits EGFR-induced ERK5 autophosphorylation (EC50 = 90 nM) and ERK5 enzymatic activity (IC50 = 162 nM).…
Product Name: VX-11eSubtitle: ERK inhibitorBiological Activity: Biological Activity of VX-11ePotent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3,…
Product Name: Trametinib DMSO solvateSubtitle: Allosteric MEK1/MEK2 kinase inhibitorBiological Activity: SMLES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5.CS(=O)CCAS NO: 1218942-37-0Standard In CHIKey: Parasite inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C28H29FIN5O5SM.Wt: 693.53General Tips: For obtaining a higher…
Product Name: Skepinone-LSubtitle: P38-MAPK inhibitor,potent and selectiveBiological Activity: Biological Activity of Skepinone-LDescription Skepinone-L is a selective inhibitor of p38 mitogen-activated protein kinase (MAPK) and TNF-α with IC50 values of 5…
Product Name: SD-06Subtitle: Biological Activity: SMLES: C1CN(CCC1C2=C(C(=NN2)C3=CC=C(C=C3)Cl)C4=NC=NC=C4)C(=O)COCAS NO: 1078166-57-0Standard In CHIKey: HSV inhibitorsStandard InChI: Typrof Compound: Appearance: Formula: C20H20ClN5O2M.Wt: 397.87General Tips: For obtaining a higher solubility , please warm the…
Product Name: SCH772984Subtitle: ERK1 and ERK2 inhibitorBiological Activity: Biological Activity of SCH772984Description SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 values of 4 nM and 1 nM, respectively.…
Product Name: SB 239063Subtitle: P38 MAP kinase inhibitorBiological Activity: Biological Activity of SB 239063Potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38α). Displays > 220-fold selectivity…